Br J Ophthalmol 2001;85:173-178
( February )
Transpupillary thermotherapy (TTT) for the treatment of choroidal
neovascularisation
R S B Newsom, J C McAlister, M Saeed, J D A McHugh
King's College
Hospital, Denmark Hill, London SE5 9RS, UK
Correspondence to: Mr R S B Newsom, Department of Vitreoretinal Surgery, Moorfields Eye
Hospital, City Road, London EC1V 2PD, UK
rbnewsom{at}dircon.co.uk
Accepted for publication 31 July 2000
AIM To
assess the effectiveness of transpupillary thermotherapy (TTT) for the
treatment of classic and occult choroidal neovascularisation (CNV).
METHODIn a
retrospective, case selected, open label trial 44 eyes of 42 patients
with CNV secondary to age related macular degeneration (ARMD) were
studied. 44 eyes with angiographically defined CNV were treated with
diode laser (810 nm) TTT. Laser beam sizes ranged between 0.8 and 3.0 mm and power settings between 250-750 mW. Treatment was given in one
area for 1 minute, the end point being no visible change, or a slight
greying of the retina. Outcome was assessed with Snellen visual acuity
and clinical examination; in 24/44 patients angiographic follow up was available.
RESULTS12
predominantly classic CNV and 32 predominantly occult membranes were
followed up for a mean of 6.1 months (range 2-19). Mean change in
vision for classic membranes was  0.75 (SD 1.75) Snellen lines and
occult membranes was 0.66 Snellen lines (2.1) (p>0.05).
Predominantly classic membranes were closed in 75% (95% CI:
62.5-87.5) of eyes, remained persistent in 25% (95% CI: 12.5-37.5); no recurrences occurred. Predominantly occult membranes were closed in
78% (95% CI: 70.1-85.3) of eyes, remained persistent in 12.5% (95%
CI: 6.6-18.5), and were recurrent in 5.1% (95% CI: 4.2-14.3).
CONCLUSIONSTranspupillary
thermotherapy is a potential treatment for CNV. It is able to close
choroidal neovascularisation while maintaining visual function in
patients with classic and occult disease. Further trials of TTT are
needed to compare this intervention with the natural history and other
treatment modalities.
© 2001 by British Journal of Ophthalmology
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eLetters:
Read all eLetters
- Transpupillary thermotherapy in choroidal neovascularization
- Erdem Ergun
- BJO Online, 19 Apr 2001
[Full text]
- Re: Transpupillary thermotherapy in choroidal neovascularization
- R S B Newsom
- BJO Online, 13 Aug 2001
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