Br J Ophthalmol 2001;85:80-84
( January )
Effect of ADCON-L on adjustable strabismus surgery in rabbits
Mi Young Choia, Soo-Jae Auha, Dong Gyu Choib, Bong Leen Changc
a Department of
Ophthalmology, College of Medicine, Chungbuk National University,
Cheongju, Korea, b Department of Ophthalmology, College of
Medicine, Hallym University, Seoul, Korea, c Department of Ophthalmology, College of
Medicine, Seoul National University, Seoul, Korea
Correspondence to: Dr Mi Young Choi, Department of
Ophthalmology, College of Medicine, Chungbuk National University
Hospital 62 Kaeshin-Dong, Heungduk-Gu, Cheongju, Chungbuk, 361-240, Korea
mychoi{at}med.chungbuk.ac.kr
Accepted for publication 23 June 2000
BACKGROUND/AIMS
In
search of a way to prevent postoperative adhesion after strabismus
surgery, an animal study was performed to assess the effect of a gel
consisting of a polyglycan ester in a gelatin matrix (ADCON-L).
METHODSBilateral
recessions of superior rectus muscle (SR) were performed on 16 rabbits.
ADCON-L was applied beneath and over the SR in the right eyes of all
rabbits, while the operative fields in the left eyes were irrigated
with a balanced salt solution (BSS). The adjustment was performed on
each SR at 4 and 7 days postoperatively on the same eye. The length and
force of the adjustment and the degree of adhesion were recorded. At 3 weeks postoperatively, disinsertional force was measured in several of
the eyes, and the other eyes were enucleated.
RESULTSThe length of
the adjustment was longer and the force of the adjustment was less in
the ADCON-L group than in the BSS treated group at 4 and 7 days
postoperatively (p=0.00). A significant reduction (p=0.00) in the
degree of adhesion was noted in eyes treated with ADCON-L. There was no
significant difference in disinsertional force between the two groups.
Histopathological evaluation of the muscle revealed decreased fibrosis
of perimuscular connective tissue in eyes treated with ADCON-L at 3 weeks postoperatively.
CONCLUSIONThis study
suggests that ADCON-L helps to prevent postoperative adhesion in
rabbits and enables adjustment twice within 7 days postoperatively
without complications.
© 2001 by British Journal of Ophthalmology
