Br J Ophthalmol 2000;84:1045-1049
( September )
Optic nerve oxygen tension: effects of intraocular pressure and
dorzolamide
M la Coura, J F Kiilgaarda, T Eysteinssonb, A K Wienckea, K Bangc, J Dollerupc, P K Jensena, E Stefánssonb
a Eye Department,
National University Hospital, University of Copenhagen, Denmark, b University of Iceland, Reykjavik, Iceland, c Merck Sharp & Dohme, Glostrup, Denmark
Correspondence to: Dr M la Cour,
Eye Department 2061, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø,
Denmark m.la.cour{at}dadlnet.dk
Accepted for publication 28 April 2000
AIM To investigate the
influence of acute changes in intraocular pressure on the oxygen
tension in the vicinity of the optic nerve head under control
conditions and after intravenous administration of 500 mg of the
carbonic anhydrase inhibitor dorzolamide.
METHODSDomestic pigs
were used as experimental animals. Oxygen tension was measured by means
of a polarographic electrode in the vitreous 0.5 mm anterior to the
optic disc. This entity is called the optic nerve oxygen tension.
Intraocular pressure was controlled by a hypodermic needle inserted
into the anterior chamber and connected to a saline reservoir.
RESULTSWhen the
intraocular pressure was clamped at 20 cm H2O optic nerve
oxygen tension was 20 (5) mm Hg (n=8). Intravenous administration of
dorzolamide caused an increase in optic nerve oxygen tension of 43 (8)% (n=6). Both before and after administration of dorzolamide optic
nerve oxygen tension was unaffected by changes in intraocular pressure,
as long as this pressure remained below 60 cm H2O. At intraocular pressures of 60 cm H2O and below, dorzolamide
significantly increased optic nerve oxygen tension.
CONCLUSIONIntravenous
administration of 500 mg dorzolamide increases the oxygen tension at
the optic nerve head during acute increases in intraocular pressure.
© 2000 by British Journal of Ophthalmology
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