BJO

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER


[Advanced]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this link to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Add article to my folders
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ghiasi, H.
Right arrow Articles by Wechsler, S. L
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ghiasi, H.
Right arrow Articles by Wechsler, S. L
Br J Ophthalmol 2000;84:408-412 ( April )

Both CD4+ and CD8+ T cells are involved in protection against HSV-1 induced corneal scarring

Homayon Ghiasia b, Steve Caia, Guey-Chuen Pernga, Anthony B Nesburna b, Steven L Wechslera b

a Ophthalmology Research, Cedars-Sinai Burns and Allen Research Institute, Los Angeles, USA, b Department of Ophthalmology, UCLA School of Medicine, Los Angeles, USA

Correspondence to: Homayon Ghiasi, Ophthalmology Research, Davis Building Room 5069, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA

Accepted for publication 15 November 1999

AIM---To determine the relative impact of CD4+ T cells and CD8+ T cells in protecting mice against ocular HSV-1 challenge.
METHODS---CD4+ T cell knockout mice (CD4-/- mice), CD8+ T cell knockout mice (CD8-/- mice), and mice depleted for CD4+ or CD8+ T cells by antibody (CD4+ depleted and CD8+ depleted mice), were examined for their ability to withstand HSV-1 ocular challenge. The parental mice for both knockout mice were C57BL/6J.
RESULTS---These results suggest that: (1) both CD4+ deficient mice (CD4-/- and CD4+ depleted mice) and CD8+ deficient mice (CD8-/-, and CD8+ depleted mice) developed significantly more corneal scarring than their C57BL/6J parental strain; (2) the duration of virus clearance from the eyes of the CD4+ deficient mice was 4 days longer than that of the CD8+ deficient mice; and (3) the severity of corneal scarring in the CD4+ deficient mice was approximately twice that of the CD8+ deficient mice.
CONCLUSIONS---It was reported here that: (1) CD4+ and CD8+ T cells were both involved in protection against lethal ocular HSV-1 infection; and (2) CD4+ and CD8+ T cells were both involved in protection against HSV-1 induced corneal scarring.

© 2000 by British Journal of Ophthalmology


This article has been cited by other articles:


Home page
 J. Immunol.Home page
T. R. Wuest and D. J. J. Carr
Dysregulation of CXCR3 Signaling due to CXCL10 Deficiency Impairs the Antiviral Response to Herpes Simplex Virus 1 Infection
J. Immunol., December 1, 2008; 181(11): 7985 - 7993.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
P. Lundberg, H. Openshaw, M. Wang, H.-J. Yang, and E. Cantin
Effects of CXCR3 Signaling on Development of Fatal Encephalitis and Corneal and Periocular Skin Disease in HSV-Infected Mice Are Mouse-Strain Dependent
Invest. Ophthalmol. Vis. Sci., September 1, 2007; 48(9): 4162 - 4170.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. J. Lepisto, M. Xu, H. Yagita, A. D. Weinberg, and R. L. Hendricks
Expression and function of the OX40/OX40L costimulatory pair during herpes stromal keratitis
J. Leukoc. Biol., March 1, 2007; 81(3): 766 - 774.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
A. J. Lepisto, G. M. Frank, M. Xu, P. M. Stuart, and R. L. Hendricks
CD8 T Cells Mediate Transient Herpes Stromal Keratitis in CD4-Deficient Mice.
Invest. Ophthalmol. Vis. Sci., August 1, 2006; 47(8): 3400 - 3409.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
D. J. J. Carr, J. Ash, T. E. Lane, and W. A. Kuziel
Abnormal immune response of CCR5-deficient mice to ocular infection with herpes simplex virus type 1.
J. Gen. Virol., March 1, 2006; 87(Pt 3): 489 - 499.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Lang and J. Nikolich-Zugich
Development and Migration of Protective CD8+ T Cells into the Nervous System following Ocular Herpes Simplex Virus-1 Infection
J. Immunol., March 1, 2005; 174(5): 2919 - 2925.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
P. M. Stuart, B. Summers, J. E. Morris, L. A. Morrison, and D. A. Leib
CD8+ T cells control corneal disease following ocular infection with herpes simplex virus type 1
J. Gen. Virol., July 1, 2004; 85(7): 2055 - 2063.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
L. BenMohamed, G. Bertrand, C. D. McNamara, H. Gras-Masse, J. Hammer, S. L. Wechsler, and A. B. Nesburn
Identification of Novel Immunodominant CD4+ Th1-Type T-Cell Peptide Epitopes from Herpes Simplex Virus Glycoprotein D That Confer Protective Immunity
J. Virol., September 1, 2003; 77(17): 9463 - 9473.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
H. Ghiasi, Y. Osorio, G.-C. Perng, A. B. Nesburn, and S. L. Wechsler
Overexpression of Interleukin-2 by a Recombinant Herpes Simplex Virus Type 1 Attenuates Pathogenicity and Enhances Antiviral Immunity
J. Virol., August 12, 2002; 76(18): 9069 - 9078.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
H. Ghiasi, Y. Osorio, G.-C. Perng, A. B. Nesburn, and S. L. Wechsler
Recombinant Herpes Simplex Virus Type 1 Expressing Murine Interleukin-4 Is Less Virulent than Wild-Type Virus in Mice
J. Virol., October 1, 2001; 75(19): 9029 - 9036.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
Terms and conditions relating to subscriptions purchased online  ¦  Website terms and conditions  ¦  Privacy policy
Copyright © 2000 by the BMJ Publishing Group Ltd.