Br J Ophthalmol 1999;83:1183-1185
( October )
Scientific correspondence
Penetration of topical, oral, and combined administered ofloxacin
into the subretinal fluid
Osman Çekiça, Cosar Batmana, Ümit Yasarb, Yüksel Totana, Nursabah E Bascib, Atilla Bozkurtb, Orhan Zilelioglua, S Oguz Kayaalpb
a SSK
Ankara Eye Hospital, Department of Vitreoretinal Surgery, Ankara,
Turkey, b Hacettepe University, Faculty of
Medicine Department of Pharmacology, Ankara, Turkey
Correspondence to: Osman Çekiç, MD, 54 Basak Sokak, No 7, 06660 Kucukesat Ankara,
Turkey
Accepted for publication 25 June 1999
AIMS
To assess the
subretinal fluid (SRF) levels of ofloxacin following topical, oral or
combined administration.
METHODS31 patients
undergoing conventional retinal reattachment surgery were randomly
assigned to three groups. Nine patients received topical ofloxacin, 11 patients received oral ofloxacin, and the other 11 patients received
combined administration. Collected SRF samples were analysed for drug
level by using high performance liquid chromatography.
RESULTSSRF drug
levels after oral and combined administration were significantly higher
than that after topical administration (p=0.0002 and p=0.0002,
respectively) while there was no significant difference between oral
and combined administration (p=0.0844).
CONCLUSIONSOcular
bioavailability of ofloxacin in SRF after oral and combined
administration is equivalent. The addition of oral ofloxacin to topical
therapy increased drug SRF penetration sixfold.
© 1999 by British Journal of Ophthalmology
