Br J Ophthalmol 1998;82:684-690 ( June )
Retinal nerve fibre layer polarimetry: histological and clinical
comparison
J E Morgan,a
A Waldock,b
G Jeffery,c
A Coweyd
a Cardiff Eye Unit, University Hospital of Wales, Cardiff
CF4 4XW, b Bristol Eye Hospital, Lower
Maudlin Street, Bristol BS1 2LX, c Institute of
Ophthalmology, Bath Street, London EC1 2PD, d Department of Psychology, South Parks Road, Oxford
OX1 3PT
Correspondence to: Mr J E Morgan,
Cardiff Eye Unit, University Hospital of Wales, Heath Park Cardiff CF4
4XW.
Accepted for publication 9 January
1998
AIMS To compare histological thickness of the
retinal nerve fibre layer in the primate with retardation measurements
obtained in vivo using the Mark II Nerve Fiber Analyzer (NFA, Laser
Diagnostic Technologies, San Diego, USA).
METHODSScanning laser polarimetry was performed
on both eyes of a healthy anaesthetised adult primate (Macaca
mulatta). The retinal nerve fibre layer thickness was measured
in the eye with the best polarimetry image. A nerve fibre layer
thickness map was scaled and aligned to a retardation map to permit
correlation of retardation and thickness measurements.
RESULTSRetinal nerve fibre layer thickness
measurements could be satisfactorily aligned with corresponding
retardation values at 216 locations. The overall correlation
coefficient for nerve fibre layer thickness and retardation was
r = 0.70 (n = 216, p <0.001). Regional comparison
showed the best correlation (r = 0.76, n = 45, p
<0.001) occurred inferior to the optic disc. Less positive but still
highly significant correlations were seen superiorly and temporally
(r = 0.52, n = 26, p = 0.007 and
r = 0.49, n = 86, p = <0.001 respectively), with
the lowest correlation occurring at the nasal aspect of the disc
(r = 0.06, n = 67, p = 0.64).
CONCLUSIONSIn the primate eye, retinal nerve
fibre layer thickness shows a positive correlation with retardation
measurements obtained with the nerve fibre analyser. However, since the
correlation coefficient varied around the optic disc, further
evaluation of the device is advised before its routine clinical use.
Keywords:
nerve fibre layer;
polarimetry;
glaucoma;
optic
disc
© 1998 by British Journal of Ophthalmology
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