Br J Ophthalmol 1998;82:267-275 ( March )
Multifocal electroretinography in patients with Stargardt's
macular dystrophy
U Kretschmann,
M W Seeliger,
K Ruether,
T Usui,
E Apfelstedt-Sylla,
E Zrenner
University Eye
Hospital, Department for Pathophysiology of Vision and
Neuro-Ophthalmology, Tuebingen, Germany
Correspondence to: Dr Ulf
Kretschmann, University Eye Hospital, Department for Pathophysiology of
Vision and Neuro-Ophthalmology, Schleichstrasse 12-16, 72076 Tuebingen, Germany.
Accepted for publication 29 September 1997
AIMS To describe the topography of multifocal
electroretinograms (ERGs) and to explore its diagnostic value in
patients with Stargardt's macular dystrophy (SMD).
METHODS51 patients with SMD were examined by
means of the m-sequence technique to characterise the topography of
electroretinographic responses in the central visual field. The results
were compared with data from 30 normal volunteers.
RESULTSIn 49 of 51 patients with SMD, macular
electroretinographic activity was markedly diminished or
non-detectable. Towards more peripheral areas, ERG responses of the SMD
patients approached those of normals. Implicit times were not markedly
delayed at any eccentricity.
CONCLUSIONIn contrast with Ganzfeld
electroretinography, multifocal electroretinography is useful to
detect foveal dysfunction in SMD. Areas of dysfunction were found to be
usually larger than expected from psychophysical measurements and
morphological alteration. In early stages of the disease it was
possible to detect foveal dysfunction, even in patients lacking
morphological fundus changes and with good visual acuity.
Keywords:
Stargardt's macular dystrophy;
fundus
flavimaculatus;
electroretinography
© 1998 by British Journal of Ophthalmology
This article has been cited by other articles:
|
|
|
|
 
S. Maia-Lopes, E. D. Silva, M. F. Silva, A. Reis, P. Faria, and M. Castelo-Branco
Evidence of Widespread Retinal Dysfunction in Patients with Stargardt Disease and Morphologically Unaffected Carrier Relatives
Invest. Ophthalmol. Vis. Sci.,
March 1, 2008;
49(3):
1191 - 1199.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Y. C. Lee, A. H. C. Koh, T. Aung, V. H. K. Yong, K. Yeung, C.-L. Ang, and E. N. Vithana
Characterization of Bietti Crystalline Dystrophy Patients with CYP4V2 Mutations
Invest. Ophthalmol. Vis. Sci.,
October 1, 2005;
46(10):
3812 - 3816.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A Schuster, N Weisschuh, H Jagle, D Besch, A R Janecke, H Zierler, S Tippmann, E Zrenner, and B Wissinger
Novel rhodopsin mutations and genotype-phenotype correlation in patients with autosomal dominant retinitis pigmentosa
Br. J. Ophthalmol.,
October 1, 2005;
89(10):
1258 - 1264.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Li, M. Horiguchi, and S. Kishi
Tomographic and Multifocal Electroretinographic Features of Idiopathic Epimacular Membranes
Arch Ophthalmol,
October 1, 2004;
122(10):
1462 - 1467.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Bellmann, M. M. Neveu, H. P. N. Scholl, C. R. Hogg, P. P. Rath, S. Jenkins, A. C. Bird, and G. E. Holder
Localized Retinal Electrophysiological and Fundus Autofluorescence Imaging Abnormalities in Maternal Inherited Diabetes and Deafness
Invest. Ophthalmol. Vis. Sci.,
July 1, 2004;
45(7):
2355 - 2360.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Nagasaka, M. Horiguchi, Y. Shimada, and M. Yuzawa
Multifocal Electroretinograms in Cases of Central Areolar Choroidal Dystrophy
Invest. Ophthalmol. Vis. Sci.,
April 1, 2003;
44(4):
1673 - 1679.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K Dietrich, F K Jacobi, S Tippmann, R Schmid, E Zrenner, B Wissinger, and E Apfelstedt-Sylla
A novel mutation of the RP1 gene (Lys778ter) associated with autosomal dominant retinitis pigmentosa
Br. J. Ophthalmol.,
March 1, 2002;
86(3):
328 - 332.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kondo, Y. Miyake, N. Kondo, A. Tanikawa, S. Suzuki, M. Horiguchi, and H. Terasaki
Multifocal ERG Findings in Complete Type Congenital Stationary Night Blindness
Invest. Ophthalmol. Vis. Sci.,
May 1, 2001;
42(6):
1342 - 1348.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
H. P. N. Scholl, J. Kremers, R. Vonthein, K. White, and B. H. F. Weber
L- and M-Cone-Driven Electroretinograms in Stargardt's Macular Dystrophy-Fundus Flavimaculatus
Invest. Ophthalmol. Vis. Sci.,
May 1, 2001;
42(6):
1380 - 1389.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. W. Seeliger and K. Narfström
Functional Assessment of the Regional Distribution of Disease in a Cat Model of Hereditary Retinal Degeneration
Invest. Ophthalmol. Vis. Sci.,
June 1, 2000;
41(7):
1998 - 2005.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
H. Wilhelm, J. Neitzel, B. Wilhelm, S. Beuel, H. Lüdtke, U. Kretschmann, and E. Zrenner
Pupil Perimetry using M-Sequence Stimulation Technique
Invest. Ophthalmol. Vis. Sci.,
April 1, 2000;
41(5):
1229 - 1238.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
C.-H. Piao, M. Kondo, A. Tanikawa, H. Terasaki, and Y. Miyake
Multifocal Electroretinogram in Occult Macular Dystrophy
Invest. Ophthalmol. Vis. Sci.,
February 1, 2000;
41(2):
513 - 517.
[Abstract]
[Full Text]
|
|
|
|
|
