BJO

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER


[Advanced]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this link to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Add article to my folders
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cassidy, L
Right arrow Articles by Kennedy, S
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cassidy, L
Right arrow Articles by Kennedy, S
Topic Collections
Right arrowRelevant Article
Br J Ophthalmol 1998;82:181-185 ( February )

Platelet derived growth factor and fibroblast growth factor basic levels in the vitreous of patients with vitreoretinal disorders

L Cassidy,a b P Barry,b C Shaw,d M J Duffy,e S Kennedya c

a Research Department, The Royal Victoria Eye & Ear Hospital, Dublin, b Department of Ophthalmology, The Royal Victoria Eye & Ear Hospital, Dublin, c National Ophthalmic Pathology Laboratory, The Royal Victoria Eye & Ear Hospital, Dublin, d University College Dublin, Belfield, Dublin, e Department of Nuclear Medicine, St Vincent's Hospital, Dublin

Correspondence to: Miss Lorraine Cassidy, Ophthalmology Department, Clarendon Wing, Leeds General Infirmary, Belmont Grove, Leeds LS2 9NS.

Accepted for publication 13 August 1997

AIM---To determine the potential role of basic fibroblast growth factor (bFGF) and platelet derived growth factor (PDGF) in the pathogenesis of proliferative vitreoretinopathy (PVR).
METHODS---An enzyme linked immunosorbent assay technique was used to determine the quantities of bFGF and PDGF in 38 vitreous samples taken from patients undergoing trans pars plana vitrectomy (PPV) for a variety of vitreoretinal disorders.
RESULTS---bFGF levels ranged from undetectable to 318.7 pg/ml. The mean concentration was 27.57 pg/ml. PDGF levels ranged from undetectable to 160 pg/ml, the mean concentration being 40.06 pg/ml. Eight of 13 patients with clinical evidence of retinal detachment (RD) and PVR had significantly elevated bFGF concentrations, whereas only one of 11 patients with RD and no PVR had detectable bFGF; seven of eight patients with RD and PVR had elevated PDGF concentrations in the vitreous, whereas all 10 patients with RD and no PVR had no detectable vitreous PDGF. Eight patients with vitreous haemorrhage had raised PDGF concentrations, and the levels were particularly high (>120 pg/ml) in those two patients with active neovascularisation. Two out of nine patients with vitreous haemorrhage had raised bFGF levels.
CONCLUSIONS---bFGF and PDGF concentrations are elevated in PVR even in the absence of vitreous haemorrhage, and not in patients with RD uncomplicated by PVR. This observation suggests that both cytokines may be involved in the pathogenesis of PVR.

Keywords: basic fibroblast growth factor; platelet derived growth factor; proliferative vitreoretinopathy

© 1998 by British Journal of Ophthalmology

Relevant Article

Growth factors in proliferative vitreoretinopathy
DAVID G CHARTERIS
Br. J. Ophthalmol. 1998 82: 106. [Extract] [Full Text]



This article has been cited by other articles:


Home page
 IOVSHome page
H. Kaneko, K. M. Nishiguchi, M. Nakamura, S. Kachi, and H. Terasaki
Retardation of Photoreceptor Degeneration in the Detached Retina of rd1 Mouse
Invest. Ophthalmol. Vis. Sci., February 1, 2008; 49(2): 781 - 787.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
H. Lei, P. Hovland, G. Velez, A. Haran, D. Gilbertson, T. Hirose, and A. Kazlauskas
A Potential Role for PDGF-C in Experimental and Clinical Proliferative Vitreoretinopathy
Invest. Ophthalmol. Vis. Sci., May 1, 2007; 48(5): 2335 - 2342.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
S. Saika, O. Yamanaka, I. Nishikawa-Ishida, A. Kitano, K. C. Flanders, Y. Okada, Y. Ohnishi, Y. Nakajima, and K. Ikeda
Effect of Smad7 Gene Overexpression on Transforming Growth Factor beta-Induced Retinal Pigment Fibrosis in a Proliferative Vitreoretinopathy Mouse Model
Arch Ophthalmol, May 1, 2007; 125(5): 647 - 654.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
S. Mukherjee and C. Guidry
The Insulin-Like Growth Factor System Modulates Retinal Pigment Epithelial Cell Tractional Force Generation
Invest. Ophthalmol. Vis. Sci., April 1, 2007; 48(4): 1892 - 1899.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
S. G. Priglinger, C. S. Alge, T. C. Kreutzer, A. S. Neubauer, C. Haritoglou, A. Kampik, and U. Welge-Luessen
Keratinocyte Transglutaminase in Proliferative Vitreoretinopathy
Invest. Ophthalmol. Vis. Sci., November 1, 2006; 47(11): 4990 - 4997.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
C. S. Alge, S. G. Priglinger, D. Kook, H. Schmid, C. Haritoglou, U. Welge-Lussen, and A. Kampik
Galectin-1 Influences Migration of Retinal Pigment Epithelial Cells
Invest. Ophthalmol. Vis. Sci., January 1, 2006; 47(1): 415 - 426.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
K. Hirayama, Y. Hata, Y. Noda, M. Miura, I. Yamanaka, H. Shimokawa, and T. Ishibashi
The Involvement of the Rho-Kinase Pathway and Its Regulation in Cytokine-Induced Collagen Gel Contraction by Hyalocytes
Invest. Ophthalmol. Vis. Sci., November 1, 2004; 45(11): 3896 - 3903.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
R H Y Asaria, C H Kon, C Bunce, C S Sethi, G A Limb, P T Khaw, G W Aylward, and D G Charteris
Silicone oil concentrates fibrogenic growth factors in the retro-oil fluid
Br. J. Ophthalmol., November 1, 2004; 88(11): 1439 - 1442.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
M. Hollborn, G. Birkenmeier, A. Saalbach, I. Iandiev, A. Reichenbach, P. Wiedemann, and L. Kohen
Expression of LRP1 in Retinal Pigment Epithelial Cells and Its Regulation by Growth Factors
Invest. Ophthalmol. Vis. Sci., June 1, 2004; 45(6): 2033 - 2038.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
Y. Tanaka, J. Utsumi, M. Matsui, T. Sudo, N. Nakamura, M. Mutoh, A. Kajita, S. Sone, K. Kigasawa, M. Shibuya, et al.
Purification, Molecular Cloning, and Expression of a Novel Growth-Promoting Factor for Retinal Pigment Epithelial Cells, REF-1/TFPI-2
Invest. Ophthalmol. Vis. Sci., January 1, 2004; 45(1): 245 - 252.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
K. Yamane, A. Minamoto, H. Yamashita, H. Takamura, Y. Miyamoto-Myoken, K. Yoshizato, T. Nabetani, A. Tsugita, and H. K. Mishima
Proteome Analysis of Human Vitreous Proteins
Mol. Cell. Proteomics, November 1, 2003; 2(11): 1177 - 1187.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
J Troger, S Sellemond, G Kieselbach, M Kralinger, E Schmid, B Teuchner, Q A Nguyen, E Schretter-Irschick, and W Gottinger
Inhibitory effect of certain neuropeptides on the proliferation of human retinal pigment epithelial cells
Br. J. Ophthalmol., November 1, 2003; 87(11): 1403 - 1408.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
R Nicoletti, I Venza, G Ceci, M Visalli, D Teti, and A Reibaldi
Vitreous polyamines spermidine, putrescine, and spermine in human proliferative disorders of the retina
Br. J. Ophthalmol., August 1, 2003; 87(8): 1038 - 1042.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
S. K. Parapuram, R. Ganti, R. C. Hunt, and D. M. Hunt
Vitreous Induces Components of the Prostaglandin E2 Pathway in Human Retinal Pigment Epithelial Cells
Invest. Ophthalmol. Vis. Sci., April 1, 2003; 44(4): 1767 - 1774.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
I. Milenkovic, M. Weick, P. Wiedemann, A. Reichenbach, and A. Bringmann
P2Y Receptor-Mediated Stimulation of Muller Glial Cell DNA Synthesis: Dependence on EGF and PDGF Receptor Transactivation
Invest. Ophthalmol. Vis. Sci., March 1, 2003; 44(3): 1211 - 1220.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
E. H. Van Aken, O. De Wever, L. Van Hoorde, E. Bruyneel, J.-J. De Laey, and M. M. Mareel
Invasion of Retinal Pigment Epithelial Cells: N-cadherin, Hepatocyte Growth Factor, and Focal Adhesion Kinase
Invest. Ophthalmol. Vis. Sci., February 1, 2003; 44(2): 463 - 472.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
J. J. Lee, J. K. Park, Y.-T. Kim, B.-M. Kwon, S. G. Kang, Y. D. Yoo, Y. S. Yu, and H. Chung
Effect of 2'-Benzoyl-oxycinnamaldehyde on RPE Cells In Vitro and in an Experimental Proliferative Vitreoretinopathy Model
Invest. Ophthalmol. Vis. Sci., September 1, 2002; 43(9): 3117 - 3124.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
P. A. Hogg, I. Grierson, and P. Hiscott
Direct Comparison of the Migration of Three Cell Types Involved in Epiretinal Membrane Formation
Invest. Ophthalmol. Vis. Sci., August 1, 2002; 43(8): 2749 - 2757.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
Y. Ikuno and A. Kazlauskas
An In Vivo Gene Therapy Approach for Experimental Proliferative Vitreoretinopathy Using the Truncated Platelet-Derived Growth Factor {alpha} Receptor
Invest. Ophthalmol. Vis. Sci., July 1, 2002; 43(7): 2406 - 2411.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
Y. Ikuno, F.-L. Leong, and A. Kazlauskas
PI3K and PLC{gamma} Play a Central Role in Experimental PVR
Invest. Ophthalmol. Vis. Sci., February 1, 2002; 43(2): 483 - 489.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
Y. Ikuno and A. Kazlauskas
TGF{beta}1-Dependent Contraction of Fibroblasts Is Mediated by the PDGF{alpha} Receptor
Invest. Ophthalmol. Vis. Sci., January 1, 2002; 43(1): 41 - 46.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
Y. Ikuno, F.-L. Leong, and A. Kazlauskas
Attenuation of Experimental Proliferative Vitreoretinopathy by Inhibiting the Platelet-Derived Growth Factor Receptor
Invest. Ophthalmol. Vis. Sci., September 1, 2000; 41(10): 3107 - 3116.
[Abstract] [Full Text]

Home page
 IOVSHome page
L. Carrington, D. McLeod, and M. Boulton
IL-10 and Antibodies to TGF-{beta}2 and PDGF Inhibit RPE-Mediated Retinal Contraction
Invest. Ophthalmol. Vis. Sci., April 1, 2000; 41(5): 1210 - 1216.
[Abstract] [Full Text]

Home page
 Br. J. Ophthalmol.Home page
G A. Limb and A. H Chignell
Vitreous levels of intercellular adhesion molecule 1 (ICAM-1) as a risk indicator of proliferative vitreoretinopathy
Br. J. Ophthalmol., August 1, 1999; 83(8): 953 - 956.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
Terms and conditions relating to subscriptions purchased online  ¦  Website terms and conditions  ¦  Privacy policy
Copyright © 1998 by the BMJ Publishing Group Ltd.